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<i>Lagotis alutacea<_i> W. W. Smith

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 17β-HSD (1) 5 alpha Reductase (10) 5-HT Receptor (24) AAK1 (1) Acetolactate Synthase (ALS) (2) Acetyl-CoA Carboxylase (3) Ack1 (1) Acyltransferase (3) ADAMTS (2) ADC Antibody (1) ADC Linker (6) ADC Payload (47) Adenosine Deaminase (1) Adenosine Receptor (8) Adenylate Cyclase (7) Adrenergic Receptor (51) AIM2 (3) Akt (35) Aldehyde Dehydrogenase (ALDH) (2) Amino Acid Decarboxylase (1) Amino Acid Derivatives (50) Aminoacyl-tRNA Synthetase (1) Aminopeptidase (3) Aminotransferases (Transaminases) (2) AMPK (17) Amylases (5) Amyloid-β (21) Anaplastic lymphoma kinase (ALK) (7) Androgen Receptor (22) Angiotensin Receptor (31) Angiotensin-converting Enzyme (ACE) (42) Annexin A (1) Antibiotic (106) Antibody-Drug Conjugates (ADCs) (11) AP-1 (1) Apelin Receptor (APJ) (1) Apical Sodium-Dependent Bile Acid Transporter (1) Apolipoprotein (2) Apoptosis (385) Aquaporin (1) Arenavirus (2) Arginase (7) Arrestin (1) Aryl Hydrocarbon Receptor (13) Atg8/LC3 (3) ATM/ATR (7) ATP Synthase (2) ATTECs (2) Aurora Kinase (15) AUTACs (3) Autophagy (112) AUTOTACs (2) Bacterial (207) Bcl-2 Family (34) BCL6 (4) Bcr-Abl (29) Beta-lactamase (1) Beta-secretase (2) Biochemical Assay Reagents (311) Bradykinin Receptor (3) Btk (16) ByeTAC (2) c-Fms (1) c-Kit (2) c-Met/HGFR (9) c-Myc (8) C-type Lectin-like Receptors (CTLRs) (1) Cadherin (1) Calcium Channel (37) Calmodulin (4) CaMK (7) Cannabinoid Receptor (3) Carbonic Anhydrase (82) Carbonyl Reductase (1) Carboxylesterase (CES) (4) Casein Kinase (10) Caspase (45) CaSR (1) Cathepsin (3) CCR (5) CD19 (2) CD20 (1) CD3 (1) CDK (43) Ceramidase (1) CFTR (3) Checkpoint Kinase (Chk) (1) Chloride Channel (2) Cholecystokinin Receptor (11) Cholinesterase (ChE) (27) CMV (3) Collagen (6) Complement System (4) Constitutive Androstane Receptor (1) COX (23) CRFR (7) CRM1 (1) Cuproptosis (2) CXCR (16) Cyclic GMP-AMP Synthase (3) Cyclin G-associated Kinase (GAK) (2) Cyclophilin (2) Cytochrome P450 (33) DAGL (1) Dengue Virus (4) Deubiquitinase (9) DGK (2) Dihydroorotate Dehydrogenase (2) Dipeptidyl Peptidase (5) Disulfidptosis (1) DNA Alkylator/Crosslinker (6) DNA Methyltransferase (2) DNA Stain (2) DNA-PK (4) DNA/RNA Synthesis (112) Dopamine Receptor (7) Dopamine Transporter (2) Drug Derivative (44) Drug Intermediate (47) Drug Isomer (6) Drug Metabolite (66) Drug-Linker Conjugates for ADC (45) Dynamin (12) E1/E2/E3 Enzyme (7) E3 Ligase Ligand-Linker Conjugates (19) EAAT (1) EBV (3) EGFR (28) Elastase (4) Endogenous Metabolite (401) Endonuclease (4) Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (2) Endothelin Receptor (8) Enterovirus (2) Epigenetic Reader Domain (71) Epoxide Hydrolase (3) ERK (25) Estrogen Receptor/ERR (22) Eukaryotic Initiation Factor (eIF) (1) FAAH (1) Factor Xa (5) Factor XI (1) FAK (5) FAP (3) Farnesyl Transferase (7) Fat Mass and Obesity-associated Protein (FTO) (1) Fatty Acid Synthase (FASN) (3) Fc Receptor (FcR) (2) Ferroptosis (20) FGFR (12) Filovirus (3) FKBP (6) FLAP (1) Flavivirus (5) FLT3 (16) Fluorescent Dye (186) Formyl Peptide Receptor (FPR) (2) Free Fatty Acid Receptor (1) Fungal (71) FXR (3) G protein-coupled Bile Acid Receptor 1 (2) G Protein-coupled Receptor Kinase (GRK) (2) G-quadruplex (1) GABA Receptor (10) Galectin (1) GCGR (5) GGTase (6) GHSR (3) GLP Receptor (10) Glucokinase (1) Glucose-6-Phosphate Isomerase (GPI) (1) Glucosylceramide Synthase (GCS) (7) GLUT (6) Glutaminase (2) Glutathione Peroxidase (14) Glutathione S-transferase (3) Glycosidase (18) Glycosyltransferase (1) Glyoxalase (GLO) (11) GlyT (5) GnRH Receptor (3) GPR119 (2) GSK-3 (13) Guanylate Cyclase (2) HBV (7) HCV (13) HDAC (70) Herbicide (7) HIF/HIF Prolyl-Hydroxylase (12) Hippo (MST) (1) Histamine Receptor (9) Histone Acetyltransferase (7) Histone Demethylase (6) Histone Methyltransferase (20) HIV (64) HIV Integrase (2) HIV Protease (5) HMG-CoA Reductase (HMGCR) (2) HPV (3) HSP (15) HSV (19) Hydroxycarboxylic Acid Receptor (HCAR) (4) IAP (3) IFNAR (26) IGF-1R (7) iGluR (22) IKK (32) IKZF Family (4) Imidazoline Receptor (35) IMPDH (1) Indoleamine 2,3-Dioxygenase (IDO) (6) Influenza Virus (19) Insecticide (14) Insulin Receptor (9) Integrin (5) Interleukin Related (41) IRAK (10) IRE1 (2) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (1207) Itk (2) JAK (31) JNK (9) Keap1-Nrf2 (10) KMO (2) LAG-3 (2) LDLR (9) Leukotriene Receptor (1) Ligands for E3 Ligase (3) Ligands for Target Protein for PROTAC (8) LIM Kinase (LIMK) (2) Lipase (2) Liposome (14) Lipoxygenase (4) LOX-1 (1) LPL Receptor (6) LXR (2) LYTACs (1) mAChR (9) MAGL (2) Malate Dehydrogenase (MDH) (1) MAP3K (7) MAP4K (6) MARCKS (1) MDM-2/p53 (17) MEK (2) Melanocortin Receptor (4) Melatonin Receptor (1) MetAP (1) Methionine Adenosyltransferase (MAT) (1) mGluR (19) MHC (35) MicroRNA (46) Microtubule/Tubulin (9) Mineralocorticoid Receptor (2) Mitochondrial Metabolism (42) Mitophagy (13) Mitosis (1) Mixed Lineage Kinase (3) MMP (27) Molecular Glues (8) Monoamine Oxidase (17) Monoamine Transporter (2) Mps1 (2) mRNA (20) mTOR (29) Mucin (1) MyD88 (2) Myosin (4) Na+/K+ ATPase (6) nAChR (16) NADPH Oxidase (1) Natriuretic Peptide Receptor (NPR) (1) Necroptosis (8) NEKs (1) Neprilysin (1) Neurokinin Receptor (5) Neuropeptide B/W Receptor (6) Neuropeptide Y Receptor (5) Neurotensin Receptor (2) NF-κB (96) NKCC (1) NO Synthase (29) NOD-like Receptor (NLR) (9) Notch (4) NTPDase (1) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (77) Oct3/4 (2) Olfactory Receptor (1) Opioid Receptor (12) Orexin Receptor (OX Receptor) (1) Organoid (20) Orphan Receptor (1) Orthopoxvirus (4) Oxidative Phosphorylation (13) Oxytocin Receptor (1) P-glycoprotein (9) P2X Receptor (4) P2Y Receptor (4) p38 MAPK (21) p62 (2) p97 (2) PACAP Receptor (7) PAK (3) Paraptosis (1) Parasite (82) PARP (16) PCSK9 (2) PD-1/PD-L1 (9) PDGFR (6) PDHK (1) PDK-1 (2) Penicillin-binding protein (PBP) (5) Peptide-Drug Conjugates (PDCs) (1) PERK (5) PGE synthase (3) Phosphatase (6) Phosphodiesterase (PDE) (21) Phospholipase (2) Photosensitizer (3) Photosystem II (1) Phytohormone (1) PI3K (55) PI4P5K (1) Piezo Channel (2) Pim (5) PIN1 (2) PINK1/Parkin (1) PKA (22) PKC (22) PKD (3) PKG (8) Platelet-activating Factor Receptor (PAFR) (5) Polo-like Kinase (PLK) (2) Potassium Channel (35) PPAR (8) Pregnane X Receptor (PXR) (2) Prion Protein (1) Progesterone Receptor (2) Prostaglandin Receptor (15) PROTAC Linkers (7) PROTACs (250) Protease Activated Receptor (PAR) (4) Proteasome (31) Protein Arginine Deiminase (2) Protein Prenyltransferase (2) Proton Pump (3) Protoporphyrinogen IX oxidase (4) PSMA (6) PTEN (1) Pyroptosis (2) Pyruvate Kinase (3) Quinone Reductase (3) Radionuclide-Drug Conjugates (RDCs) (4) Raf (5) RAR/RXR (3) Ras (28) Reactive Oxygen Species (ROS) (89) Reference Standards (269) Renin (4) RET (3) Reverse Transcriptase (7) RIP kinase (11) RNA MTase (1) ROCK (13) ROR (4) ROS Kinase (6) RSV (2) RUNX (3) Salt-inducible Kinase (SIK) (1) SARS-CoV (20) Scavenger Receptor Class B type I (SR-BI） (2) Ser/Thr Kinase (2) Ser/Thr Protease (8) Serine Racemase (SR) (1) Serotonin Transporter (3) Sex Pheromone (2) SF3B1 (1) SHMT (1) SHP2 (2) Sigma Receptor (2) Sirtuin (4) Small Interfering RNA (siRNA) (38) SNIPERs (1) SOD (9) Sodium Channel (30) Somatostatin Receptor (2) SOS1 (9) SphK (3) Src (6) STAT (32) Stearoyl-CoA Desaturase (SCD) (1) Steroid Sulfatase (1) STING (29) Succinate Dehydrogenase (1) Survivin (5) SWI/SNF Complex (2) Syk (2) TAM Receptor (3) Target Protein Ligand-Linker Conjugates (5) Taste Receptor (2) Tau Protein (2) Telomerase (1) TGF-beta/Smad (12) TGF-β Receptor (41) Thrombin (1) Thymidylate Synthase (2) Thyroid Hormone Receptor (5) TMV (2) TNF Receptor (35) Toll-like Receptor (TLR) (22) Topoisomerase (240) Transferrin Receptor (1) Transketolase (1) Transmembrane Glycoprotein (12) Transthyretin (TTR) (5) TREM receptor (1) Trk Receptor (5) TROP2 (1) TRP Channel (11) TrxR (3) Tyrosinase (18) URAT1 (2) VD/VDR (5) VEGFR (18) Virus Protease (4) VISTA (1) VKOR (1) WDR5 (2) Wee1 (2) Wnt (10) Xanthine Oxidase (2) YAP (6) α-synuclein (6) β-catenin (10) γ-secretase (1)
By Research Areas:	Cancer (1695) Cardiovascular Disease (317) Endocrinology (145) Infection (483) Inflammation/Immunology (604) Metabolic Disease (467) Neurological Disease (459)
Click Chemistry:	ADC Synthesis (1) TCO (1) DBCO (13) PROTAC Synthesis (1) Azide (26) Tetrazine (2) Alkynes (20)
Oligonucleotides:	miRNA mimics (12) Guanosine (32) Flavoring Agents (1) Nucleotide Analogs (1) mRNA (20) Phospholipids (2) Antisense Oligonucleotides (2) Guanine (2) siRNAs (37) Nucleoside Analogs (39) Mouse Pre-designed siRNA Sets (9) Cationic Lipids (1) Adjuvant (2) Human Pre-designed siRNA Sets (18) Polymers (1) Solvents (1) miRNA antagomirs (10) Adenosine (1) Thickeners (1) Nucleoside Phosphoramidites (2) Rat Pre-designed siRNA Sets (10) miRNA inhibitors (10) Solubilizing Agents (1) Bases (1) Cytidine (1) miRNA agomirs (10) Guanine Nucleotide (1) MicroRNAs (42) Aptamers (5) Uridine (4) Emulsifiers (1)

4857

Inhibitors & Agonists

Screening Libraries

175

Fluorescent Dye

172

Biochemical Assay Reagents

295

Peptides

MCE Kits

Inhibitory Antibodies

607

Natural
Products

426

Recombinant Proteins

1246

Isotope-Labeled Compounds

322

Antibodies

Click Chemistry

158

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990832

Anti-MHC Class I Antibody (W6/32)	MHC	Inflammation/Immunology
Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human MHC Class I. Anti-MHC Class I Antibody (W6/32) reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. Anti-MHC Class I Antibody (W6/32) increases adherence of monocytes to human endothelial cells. Anti-MHC Class I Antibody (W6/32) can be used for the research of immunology .

HY-16992A

W-54011 5 Publications Verification	Complement System Reactive Oxygen Species (ROS)	Inflammation/Immunology
W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of ¹²⁵I-labeled C5a to human neutrophils with a K_i value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca ²⁺ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC₅₀s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively .

HY-100911

W-5 hydrochloride	Calmodulin	Neurological Disease
W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC₅₀ value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912) .

HY-100912

W-7 hydrochloride 5 Publications Verification	Phosphodiesterase (PDE) Myosin Apoptosis Calmodulin Potassium Channel	Cancer
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca ²⁺-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias .

HY-100913

W-7 isomer hydrochloride	Calmodulin	Cancer
W-7 isomer hydrochloride is an isomer of W-7 hydrochloride (HY-100912). W-7 hydrochloride is a selective calmodulin antagonist .

HY-100910

W-13 hydrochloride	CaMK	Cancer
W-13 hydrochloride is a calmodulin antagonist. W-13 hydrochloride can inhibit Tamoxifen (HY-13757A)-resistant human breast cancer cell growth .

HY-163106

W000113414_I13	Ceramidase	Cancer
W000113414_I13 is an acid ceramidase (AC) inhibitor. W000113414_I13 exhibits dose-dependent inhibition of AC with an IC₅₀ value of 6.6?μM. W000113414_I13 can be used for the research of cancer .

HY-P10951

(R)-Zadavotide guraxetan (R)-PSMA I&T; (R)-PNT-2002	PSMA	Cancer
Zadavotide guraxetan (PSMA I&T; PNT-2002) is a prostate-specific membrane antigen (PSMA) inhibitor. Zadavotide guraxetan has antitumor activity and can be used in prostate cancer-targeted research .

HY-Y0407A

Tetrapropylammonium hydroxide (40% w/w in water) TPAOH (40% w/w in water)	Biochemical Assay Reagents	Others
Tetrapropylammonium hydroxide (40% w/w in water)It is a compound belonging to the class of quaternary ammonium compounds and is a strong base with cationic properties. Tetrapropylammonium hydroxide (40% w/w in water)It is usually used as a phase transfer catalyst to promote the transfer of reactants between immiscible phases in various organic synthesis reactions. It is also used in the production of semiconductors, especially the manufacture of thin-film transistors and other electronic devices.

HY-130368

W-7	Calmodulin Potassium Channel Phosphodiesterase (PDE) Myosin Apoptosis	Cardiovascular Disease
W-7 is a selective calmodulin antagonist. W-7 inhibits the Ca ²⁺-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 μM, respectively. W-7 induces apoptosis and has antitumor and vascular relaxing activity. W-7 is a blocker of Kv4.3 and can be used for research of arrhythmias .

HY-173020

W23-1006	Anaplastic lymphoma kinase (ALK) Apoptosis	Cancer
W23-1006 is a selective and covalent ALKBH5 inhibitor. W23-1006 binds to the ALKBH5 C200 residue with an IC₅₀ value of 3.848 μM. W23-1006 shows ~30- and 8-fold stronger inhibitory activity than that against FTO and ALKBH3, respectively. W23-1006 can be used for the study of triple-negative breast cancer (TNBC) .

HY-B2227B

Lactic acid sodium (60% w/w in water) 30+ Cited Publications DL-Lactic acid sodium; E-270 sodium	Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR) Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

HY-145012S

W-19-d4 hydrochloride	Isotope-Labeled Compounds	Others
W-19-d₄ (hydrochloride) is the deuterium labeled W-19 hydrochloride .

HY-107928B

Iron–Dextran(Fe 35-40% w/w)	Biochemical Assay Reagents	Others
Iron–Dextran(Fe 35-40% w/w) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-145482

W36017	Drug Metabolite	Neurological Disease
W3601 is the impurity of Lidocaine. W3601 exhibits nerve blocking activity with the pK_a of 7.4 .

HY-145415

W13	Bacterial	Infection
W13 is a potent MsbA inhibitor. W13 is an ATPase stimulator with an EC₅₀ of 5.5 µM .

HY-163192

W6134	ROR Apoptosis	Cancer
W6134 is highly potent and selective RORγ covalent inhibitor with an IC₅₀ of 0.21 μM. W6134 exhibits excellent selectivity for RORγ over RORα, RXRγ, and ERRγ. W6134 significantly inhibits RORγ transcriptional activity W6134 inhibits the proliferation and colony formation and induces apoptosis in castration-resistant prostate cancer cells (CRPC). W6134 can be used for the research of castration-resistant prostate cancers (CRPC) .

HY-P991421

W0180	VISTA	Cancer
W0180 is a human IgG1 monoclonal antibody (mAb) targeting VISTA/B7-H5. W0180 has the potential to activate T cells. W0180 can be used in solid tumors research .

HY-18730

1400W W1400	NO Synthase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .

HY-100979

W-84 dibromide HDMPPA	mAChR	Others
W-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors, which retards [ ³H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine .

HY-18731

1400W Dihydrochloride 20+ Cited Publications	NO Synthase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .

HY-176101

Deschloro W-19 hydrochloride	Biochemical Assay Reagents	Neurological Disease
Deschloro W-19 (hydrochloride) is an analytical reference standard with structural similarity to known analgesics.

HY-168035

W4275	Histone Methyltransferase	Cancer
W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity, showing an IC₅₀ value of 17 nM. W4275 exhibits antiproliferative activity with an IC₅₀ of 230 nM against RS411 cells and significantly inhibits tumor growth in the RS411 tumor xenograft model. Pharmacokinetic analysis in mice demonstrates that W4275 has good oral bioavailability (F of 27.34%). W4275 holds promise for use in cancer research .

HY-18731R

1400W Dihydrochloride (Standard)	NO Synthase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
1400W (Dihydrochloride) (Standard) is the analytical standard of 1400W (Dihydrochloride). This product is intended for research and analytical applications. 1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .

HY-N8097

Kushenol W	Bacterial	Infection
Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .

HY-P3844

Biotinyl-neuropeptide W-23 (human)	Transmembrane Glycoprotein Neuropeptide B/W Receptor	Neurological Disease
Biotinyl-neuropeptide W-23 (human) is a biotinylated Neuropeptide W-23 (human) (HY-P1035). Neuropeptide W-23 (human) is an agonist of NPBW1 (GPR7) and NPBW2 (GPR8) .

HY-153190

W1131	Oxidative Phosphorylation STAT Ferroptosis	Cancer
W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (HY-90006). W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway .

HY-101578

2614W94	Monoamine Oxidase	Neurological Disease
2614W94 is a selective, reversible and orally active monoamine oxidase-A (MAO-A) inhibitor with an IC₅₀ of 5 nM and a K_i of 1.6 nM. 2614W94 shows no significant inhibition of MAO-B. 2614W94 has antidepressant and anxiolytic effects .

HY-N15011

Ganoderic acid W	Others	Cancer
Ganoderic acid W is a natural product with anti-tumor activity .

HY-19282A

(5R)-BW-4030W92	Sodium Channel	Neurological Disease
(5R)-BW-4030W92 is the R enantiomer of BW-4030W92. BW-4030W92 is a non-selective, voltage-, and use-dependent sodium channel antagonist.

HY-153190A

W1131 TFA	Ferroptosis STAT	Cancer
W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. W1131 inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. W1131 effectively alleviates cancer cell chemoresistance to 5-FU (HY-90006). W1131 regulates the cell cycle, DNA damage response, and oxidative phosphorylation, including the IL6-JAK-STAT3 pathway and the ferroptosis pathway .

HY-N14602

Rifamycin W	Bacterial	Infection
Rifamycin W has anti-Gram-positive bacterial activity .

HY-U00204

Nisobamate W1015	Drug Derivative	Neurological Disease
Nisobamate (W1015) is a tranquilizer.

HY-118311

(Z)-W 3699 (Z)-Probilin; (Z)-Secrebil; (Z)-Piprozolin	Others	Metabolic Disease
(Z)-W 3699 is a potential choleretic. (Z)-W 3699 can increase the solubility of cholesterol in the gallbladder by altering the secretion of micellar bile acids. (Z)-W 3699 can prevent the formation of cholesterol-containing gallstones in dogs.

HY-116088

W123	LPL Receptor	Inflammation/Immunology
W123, a FTY720 analog, is a competitive sphingosine 1-phosphate type 1 (S1P1) receptor antagonist. W123 is measured by GTPγS activation, MAPK recruitment, cell migration, and ligand-induced receptor internalization .

HY-106537

W 3699 Probilin; Secrebil; Piprozolin	Others	Metabolic Disease
W 3699 (Probilin; Secrebil; Piprozolin) is a choleretic agent that can be used in the study of biliary diseases .

HY-N5154

Sanggenon W	Others	Others
Sanggenon W is an isoprenyl flavonoid extracted from mulberry root bark .

HY-19264

264W94	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action .

HY-171790

W-2451 NSC 294839	5-HT Receptor	Neurological Disease
W-2451 (NSC 294839) is a selective serotonin 5-HT₂ receptor antagonist. W-2451 is promising for research of neurological disorders .

HY-P1175

L-R4W2	TRP Channel	Neurological Disease
L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic .

HY-N11531

Kuwanon W	Others	Others
Kuwanon W is a natural product that can be isolated from the root bark of Morus lhou .

HY-N7294

Taxuspine W	Others	Others
Taxuspine W is a natural product, that can be isolated from the Japanese Yew Taxus cuspidata .

HY-B2056

Triforine CELA W 524	Fungal	Infection Inflammation/Immunology
Triforine (CELA W 524), a systemic fungicide, was shown to display a moderate to distinct fungitoxic activity in vitro towards several pathogenic and non-pathogenic fungi .

HY-147986

hCA I-IN-2	Carbonic Anhydrase	Cancer
hCA I-IN-2 (Compound 6d) is a selective human carbonic anhydrase I (hCA I) inhibitor with K_i values of 18.8, 375.1, 1721 and 283.9 nM against hCA I, hCA II, hCAIX and hCAXII, respectively .

HY-147985

hCA I-IN-1	Carbonic Anhydrase	Cancer
hCA I-IN-1 (Compound 6q) is a human carbonic anhydrase I (hCA I) inhibitor with K_i values of 38.3, 716.4, 940.1 and 192.8 nM against hCA I, hCA II, hCAIX and hCAXII, respectively .

HY-N1262

Scutebarbatine W Scutehenanine B	Others	Inflammation/Immunology
Scutebarbatine W is a 13-spiro subtype neo-clerodane diterpenoid. Scutebarbatine W inhibits NO production with an IC₅₀ value of 34.7 μM .

HY-100174

W-2429 NSC294836	Others	Neurological Disease
W-2429 (NSC294836) is considerably more effective than acetylsalicylic acid in inhibiting carrageenan-induced edema and in reducing brewer's yeast-induced fever in rats .

HY-P3087

Tyr-W-MIF-1	Opioid Receptor	Neurological Disease
Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia .

HY-B2227BS

Lactic acid-d4 sodium (60% w/w in water) Lactic acid-d₄ sodium	Isotope-Labeled Compounds Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR) Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Lactic acid-d₄ (DL-Lactic acid-d₄) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

HY-B2227BS1

Lactic acid-d3 sodium (60% w/w in water) Lactic acid-d₃ sodium	Isotope-Labeled Compounds Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR) Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Lactic acid-d₃ (DL-Lactic acid-d₃) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11531

Kuwanon W	Structural Classification Flavonoids Flavones Source classification Plants Moraceae Morus alba Linn.	Others
Kuwanon W is a natural product that can be isolated from the root bark of Morus lhou .

HY-N8097

Kushenol W	Infection Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields	Bacterial
Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .

HY-N15011

Ganoderic acid W	Structural Classification Natural Products Microorganisms Source classification	Others
Ganoderic acid W is a natural product with anti-tumor activity .

HY-N14602

Rifamycin W	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Rifamycin W has anti-Gram-positive bacterial activity .

HY-N5154

Sanggenon W	Structural Classification Flavonoids Flavones Source classification Plants Moraceae Morus alba Linn.	Others
Sanggenon W is an isoprenyl flavonoid extracted from mulberry root bark .

HY-N7294

Taxuspine W	Structural Classification Taxus cuspidata Siebold & Zucc. Ketones, Aldehydes, Acids Source classification Taxaceae Plants	Others
Taxuspine W is a natural product, that can be isolated from the Japanese Yew Taxus cuspidata .

HY-N1262

Scutebarbatine W Scutehenanine B	Structural Classification Terpenoids Labiatae Source classification Derris robusta Diterpenoids Plants	Others
Scutebarbatine W is a 13-spiro subtype neo-clerodane diterpenoid. Scutebarbatine W inhibits NO production with an IC₅₀ value of 34.7 μM .

HY-N14733

31-Homorifamycin W	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
31-Homorifamycin W is an antibiotic found in Amycolatopsis mediterranei .

HY-N14457

Platenomycin W2	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Antibiotic Bacterial
Platenomycin W2 is a macrolide antibiotic with anti-Gram-positive bacteria activities .

HY-N12370

Tenaxin I	Structural Classification Flavonoids Flavones Labiatae Source classification Plants Medicago truncatula Gaertn.	Others
Tenaxin I is a component extracted from Radix Scutellariae with neuraminidase inhibitory activity .

HY-N12073

Monofucosyllacto-N-hexaose I MFLNH I	Structural Classification Polysaccharides Animals Source classification Saccharides	Others
Monofucosyllacto-N-hexaose I (MFLNH I) is a composition of human milk oligosaccharide .

HY-N1939

Icariside I 1 Publications Verification Icarisid I	Flavonols Structural Classification Monophenols Flavonoids Classification of Application Fields Source classification Other Diseases Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields	Apoptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) STAT CDK Bcl-2 Family Aryl Hydrocarbon Receptor JAK Caspase IFNAR PD-1/PD-L1
Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape .

HY-N1939R

Icariside I (Standard) Icarisid I (Standard)	Flavonols Structural Classification Monophenols Flavonoids Source classification Phenols Epimedium brevicornu Maxim. Plants Berberidaceae	Reference Standards Apoptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) STAT CDK Bcl-2 Family Aryl Hydrocarbon Receptor JAK Caspase IFNAR PD-1/PD-L1
Icariside I (Standard) is the analytical standard of Icariside I (HY-N1939). This product is intended for research and analytical applications. Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape .

HY-P3055

Dendrotoxin-I DTX-I	Structural Classification Animals Cyclopeptides Source classification Animal Venoms	Potassium Channel
Dendrotoxin-I (DTX-I) is a potent K ⁺ channels blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research .

HY-N11172

Schibitubin I	Structural Classification Source classification Lignans Schisandra bicolor Cheng Phenylpropanoids Plants Schisandraceae	Others
Schibitubin I is a lignin. Schibitubin I has neuroprotective activity. Schibitubin I can be isolated from the fruits of Schisandra bicolor var. tuberculata .

HY-N12316

Goshuyuamide I	Structural Classification Alkaloids Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Indole Alkaloids	Others
Goshuyuamide-I (compound 4) is a kind of alkaloid. Goshuyuamide-I can be isolated from the fruits of Euodia rutaecarpa. Goshuyuamide-I can be used in the research of analgesics .

HY-107301

Dehydrosoyasaponin I Soyasaponin Be; DHS-I	Structural Classification Polysaccharides Leguminosae Source classification Plants Saccharides Medicago sativa L.	Potassium Channel
Dehydrosoyasaponin I (Soyasaponin Be;DHS-I), a triterpene glycoside, is a potent and reversible calcium-activated potassium (maxi-K) channels activator .

HY-N5196

Nocathiacin I Nocathiacine I	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Nocathiacin I (Nocathiacine I) is highly resistant to Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP) and multidrug resistant Enterococcus faecalis (MREF) .

HY-N1628

1β-Hydroxybaccatin I 1-Hydroxybaccatin I	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus wallichiana Zucc.	Others
1β-Hydroxybaccatin I (1-Hydroxybaccatin I) can be extracted from Taxus wallichiana .

HY-N11430

F1839-I	Structural Classification Monophenols Microorganisms Source classification Phenols	HIV
F1839-I is a compound that can be isolated from Stachybotrys. F1839-I has weak cytotoxicity and anti-HIV activity with an IC₅₀ value of 15.6 μM .

HY-N11455

Lacto-N-difucohexaose I LDFH I	Structural Classification Polysaccharides Microorganisms Source classification Saccharides	Others
Lacto-N-difucohexaose I (LNDFH I), a linker, could be used to combine oligosaccharides containing Lewis b sugar chain to water insoluble polysaccharide .

HY-N10076

Ganomycin I	Structural Classification Microorganisms Source classification Phenols Polyphenols	HMG-CoA Reductase (HMGCR) Glycosidase HIV Protease
Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects .

HY-N14084

Monamycin I	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Antibiotic Bacterial
Monamycin I is an ester peptide antibiotic. Monamycin I has activity against Gram-positive bacteria .

HY-N7141R

Spiramycin I (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Anti-parasitic Disease Research	Reference Standards Antibiotic Parasite Bacterial
Spiramycin I (Standard) is the analytical standard of Spiramycin I. This product is intended for research and analytical applications. Spiramycin I is a macrolide antibiotic and antiparasitic .

HY-N3340

Macrocarpal I	Structural Classification Terpenoids Sesquiterpenes Source classification Phenols Polyphenols Myrtaceae Plants Eucalyptus globulus Labill.	Fungal
Macrocarpal I is a phloroglucinol coupled sesquiterpenoid with antifungal activity. Macrocarpal I against C. glabrata with an IC₅₀ value of 0.75 μg/mL. Macrocarpal I can be isolated from the juvenile leaves of E. maideni .

HY-N8511

Acremine I	Structural Classification Natural Products Microorganisms Source classification	Fungal
Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew .

HY-N0612R

Siamenoside I (Standard)	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants	Reference Standards Others
Siamenoside I (Standard) is the analytical standard of Siamenoside I. This product is intended for research and analytical applications. Siamenoside I is one of the mogrosides that has several kinds of bioactivities.

HY-N8293

Eupalinolide I	Structural Classification Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae	Others
Eupalinolide I inhibits the viability of breast cancer cells. Eupalinolide I can be isolated from Eupatorium lindleyanum .

HY-120860

Sporidesmolide I	Structural Classification Microorganisms Cyclopeptides Source classification	Others
Sporidesmolide I can be found in Sporidesmium bakeri. Sporidesmolide I is promising for research into diseases such as mammalian facial eczema .

HY-N0331

Ziyuglycoside I	Triterpenes Structural Classification Classification of Application Fields Sanguisorba officinalis Linn. Terpenoids Source classification Rosaceae Plants Disease Research Fields Cancer	MDM-2/p53 Apoptosis
Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .

HY-N12127

Gymnoside I	Orchidaceae Gymnadenia conopsea (L.) R. Br. Source classification Plants	Others
Gymnoside I (compound 1) is a glycosidoxybenzyl 2-isobutylmalic acid. Gymnoside I shows antiallergic activity in passive cutaneous allergic reaction (PCA) in mice. Gymnoside I can be used in research to treat asthma, neurasthenia and chronic hepatitis .

HY-W019806

Lacto-N-fucopentaose I LNFP I	Infection Structural Classification Natural Products Polysaccharides Classification of Application Fields Animals Inflammation/Immunology Disease Research Fields Saccharides	Endogenous Metabolite CDK Reactive Oxygen Species (ROS) Apoptosis Enterovirus Bacterial
Lacto-N-fucopentaose I (LNFPI) is a human milk oligosaccharide (HMO), possessing antiviral and antibacterial activity. Lacto-N-fucopentaose I can reduce capsid protein VP1 to block virus adsorption, promote CDK2 and reduce cyclin E to recover cell cycle S phase block. Lacto-N-fucopentaose I inhibits ROS production and apoptosis in virus-infected cells. Lacto-N-fucopentaose I can also regulate intestinal microbiota to affect immune system development .

HY-N0331R

Ziyuglycoside I (Standard)	Triterpenes Structural Classification Sanguisorba officinalis Linn. Terpenoids Source classification Rosaceae Plants	Reference Standards MDM-2/p53 Apoptosis
Ziyuglycoside I (Standard) is the analytical standard of Ziyuglycoside I. This product is intended for research and analytical applications. Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .

HY-N2541

Gymnemic acid I	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Asclepiadaceae Metabolic Disease Plants Disease Research Fields Gymnema sylvestre (Retz.) Schult.	Taste Receptor mTOR Autophagy Apoptosis
Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I is an antisweetness inhibitor via human sweet receptor type 1 receptor 2 (T1R2) and T1R3. Gymnemic acid I is a ribosomal protein biosynthesis inhibitor. Gymnemic acid I has antidiabetic effects. Gymnema acid I induces autophagy-protected MIN-6 cells from apoptosis under high glucose stress by inhibiting the phosphorylation activity of mTOR .

HY-N8614

Peucedanocoumarin I	Structural Classification Natural Products Chrysanthemum × morifolium (Ramat.) Hemsl. Source classification Plants Umbelliferae	Others
Peucedanocoumarin I (compound 1) is a kind of dihydropyranocoumarin. Peucedanocoumarin I can be isolated from the root of f Peucedanum praeruptorum .

HY-N12718

Campneoside I	Structural Classification Source classification Phenols Polyphenols Bignoniaceae Plants Incarvillea compacta Maxim.	Others
Campneoside I is a bitter phenyl propanoid glycoside. Campneoside I can be isolated from the roots of Incarvillea compacta .

HY-N7218

Lysolipin I	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Lysolipin I is a lipophilic antibiotic from Streptomyces violaceoniger. Lysolipin I is active against Gram-positive and Gramnegative bacteria .

HY-N7022R

Eclalbasaponin I (Standard)	Triterpenes Structural Classification other families Terpenoids Source classification Plants	Reference Standards Others
Eclalbasaponin I (Standard) is the analytical standard of Eclalbasaponin I. This product is intended for research and analytical applications. Eclalbasaponin I is isolated from Eclipta prostrata L with antitumor activity. Eclalbasaponin I inhibits the proliferation of hepatoma cell smmc-7721 with an IC₅₀ value of 111.1703 μg/ml .

HY-N15368

Pradimicinone I	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Antibiotic Bacterial
Pradimicinone I (Compound 10), a Pradimicin A (HY-132191) analog, is an antibiotic. Pradimicinone I is promising for research of antibacterial agents .

HY-N2013

Aristolactam I 1 Publications Verification Aristololactam; Aristolactam	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Drug Metabolite Aquaporin Cadherin TGF-beta/Smad
Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis .

HY-N0360R

Dihydrotanshinone I (Standard)	Quinones Structural Classification Labiatae Samanea saman (Jacq.) Merr. Source classification Plants Phenanthrenequinones	Reference Standards SARS-CoV
Dihydrotanshinone I (Standard) is the analytical standard of Dihydrotanshinone I. This product is intended for research and analytical applications. Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

HY-122530

Juvocimene I	Structural Classification Natural Products Labiatae Source classification Plants Helenium arizonicum S.F.Blake	Insecticide
Juvocimene I is a potent juvenile hormone mimic. Juvocimene I can be isolated from the essential oil of sweet basil,Ocimum basilicum L .

HY-126476

Justicisaponin I	Justicia rotundifolia Nees Triterpenes Structural Classification Acanthaceae Terpenoids Source classification Plants	Others
Justicisaponin I can be used as an anti-fertility agent. Justicisaponin I stabilizes the acrosome membrane of sperm, and inhibits the release of acid hydrolase and sperm proteins .

HY-N15545

Thaigranatumin I	Structural Classification Natural Products Xylocarpus granatum J. Koenig Source classification Plants Meliaceae	Drug Derivative
Thaigranatumin I is a limonoid compound found in the seeds of the Thai mangrove (Xylocarpus granatum). Thaigranatumin I is promising for research of neurodegenerative diseases such as Parkinson's diseases .

HY-N0047R

Polyphyllin I (Standard)	Structural Classification Liliaceae Paris polyphylla Smith Plants Saccharides Steroids	Reference Standards JNK mTOR Akt PDK-1 Autophagy Apoptosis
Polyphyllin I (Standard) is the analytical standard of Polyphyllin I. This product is intended for research and analytical applications. Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .

HY-N8355

Beauveriolide I	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Disease Research Fields	Endogenous Metabolite
Beauveriolide I is the metabolite of Entomopathogenic Fungi Beauveria sp.. Beauveriolide I (1) exhibits moderate insecticidal activities against Spodoptera litura and Callosobruchus chinensis .

HY-N0407

Picroside I 6'-Cinnamoylcatalpol	Structural Classification Iridoids Classification of Application Fields Terpenoids Source classification Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	STAT
Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .

HY-N7052

Tubulysin I	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Payload Microtubule/Tubulin
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N1985

Acetylastragaloside I	Structural Classification Natural Products Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	Parasite
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC₅₀ values of 9.5 and 5.0 μg/mL for *T. brucei rhodesiense* and *T. cruzi*, respectively. Acetylastragaloside I can be used for the research of trypanosome infection .

HY-N0887

Isoastragaloside I 2 Publications Verification Isoastragaloside-I	Triterpenes Structural Classification other families Classification of Application Fields Leguminosae Terpenoids Source classification Metabolic Disease Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields	Others
Isoastragaloside I is a natural compound from the medicinal herb Radix Astragali; possesses the activity of elevating adiponectin production.

Cat. No.	Product Name	Chemical Structure

HY-B2227BS

Lactic acid-d4 sodium (60% w/w in water)

Lactic acid-d₄ (DL-Lactic acid-d₄) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

HY-B2227BS1

Lactic acid-d3 sodium (60% w/w in water)

Lactic acid-d₃ (DL-Lactic acid-d₃) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

HY-16305S

Maribavir-d6
Maribavir-d₆ (1263W94-d₆) is a deuterium labeled Maribavir (HY-16305). Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC₅₀ of 3 nM .

HY-16305S1

Maribavir-d6 TFA
Maribavir-d6 TFA (1263W94-d6 TFA; BW1263W94-d6 TFA; GW257406X-d6 TFA) is a deuterium labeled Maribavir (HY-16305). Maribavir is an orally active antiviral agent for cytomegalovirus (CMV) through inhibition of protein kinase UL97 and the following CMV DNA replication .

HY-W653982

Coproporphyrin I-15N4
Coproporphyrin I- ¹⁵N₄ is a ¹⁵N-labeled Coproporphyrin I (HY-113318). Coproporphyrin I is an endogenous metabolite present in urine and blood that can be used for the research of liver disease and porphyria .

HY-145012S

W-19-d4 hydrochloride
W-19-d₄ (hydrochloride) is the deuterium labeled W-19 hydrochloride .

HY-143665S

Nor-W-18-d4
Nor-W-18-d₄ is the deuterium labeled Nor-W-18 .

HY-W890109S

Spiramycin I-d3-1
Spiramycin I-d₃-1 is deuterium-labeled Spiramycin I .

HY-176316S

Troponin I, U-15N
Troponin I, U- ¹⁵N is the ¹⁵N-labeled Troponin I.

HY-124211S

Dibenzo(a,i)pyrene-d14
Dibenzo(a,i)pyrene-d₁₄ is the deuterium labeled Dibenzo(a,i)pyrene .

HY-143623S

Neo Spiramycin I-d3
Neo Spiramycin I-d₃ is the deuterium labeled Neo Spiramycin I (HY-143623) . Neo Spiramycin I (NSPI) is the active metabolite of Spiramycin (SPI) with antimicrobial activity. Neo Spiramycin is widely used in veterinary medicine .

HY-W010452S1

3-Hydroxybutyric acid-13C4 sodium
3-Hydroxybutyric acid- ¹³C₄ (sodium) is the ¹³C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids .

HY-W010452S2

3-Hydroxybutyric acid-13C2 sodium
3-Hydroxybutyric acid- ¹³C₂ (sodium) is the ¹³C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids .

HY-W008452S

H-Tyr(3-I)-OH-13C6
H-Tyr(3-I)-OH- ¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-W019776

Sudan I-d5
Sudan I-d₅ is a the deuterated Sudan I. Sudan I is a diazo-conjugate red dye and can be used as an additive to products such as oils, solvents or polishes. Sudan I inhibits growth of bacterial strains Clostridium perfringens and L. rhamnosus .

HY-P1032S2

Angiotensin I-13C6,15N (human, mouse, rat) TFA
Angiotensin I-13C6,15N (human, mouse, rat) TFA is ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensin II and is cleaved into angiotensin II by angiotensin converting enzyme (ACE) .

HY-B1411S1

i-Inositol-d1
i-Inositol-d is the deuterium labeled i-Inositol .

HY-W743804

Aclidinium-d5 bromide
Aclidinium-d₅ (LAS 34273-d₅; LAS-W 330-d₅) bromide is deuterium-labeled Aclidinium Bromide (HY-14144) .

HY-B1411S

i-Inositol-d6
i-Inositol-d₆ is the deuterium labeled i-Inositol. i-Inositol is a chemical compound, associated lipids are found in many foods, in particular fruit, especially cantaloupe and oranges.

HY-B0674S1

Ebastine-d6
Ebastine-d₆ is deuterated labeled Ebastine (HY-B0674). Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research .

HY-B0175S

Toltrazuril-d3
Toltrazuril-d₃ is deuterated labeled Toltrazuril. Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.

HY-P1032S

Angiotensin I-13C19,15N3 (human, mouse, rat)

Angiotensin I- ¹³C₁₉, ¹⁵N₃ (human, mouse, rat) is the ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .

HY-B2227BS3

Lactic acid-13C-1 sodium (20% w/w in water)

Lactic acid- ¹³C₁ (DL-Lactic acid- ¹³C₁) sodium (20% in water) is the ¹³C-labeled Lactic acid sodium . Lactic acid (DL-Lactic acid) sodium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium also has antimicrobial activity, which can be used as a food preservative .

HY-W015851S

3-Hydroxybutanoic acid-13C sodium
3-Hydroxybutanoic acid-13C- ¹³C (sodium) is the ¹³C labeled 3-Hydroxybutanoic acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .

HY-B0184S

Felbamate-d4
Felbamate-d₄ (W-554-d4) is the deuterium labeled Felbamate. Felbamate (W-554) is a potent anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA).

HY-13458S1

Droxidopa-13C2,15N hydrochloride
Droxidopa- ¹³C₂, ¹⁵N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood-brain barrier .

HY-W010248S

2-Phenylglycine-d5
2-Phenylglycine-d₅ is the deuterium labeled 2-Phenylglycine. 2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period .

HY-B0184S1

Felbamate-d5
Felbamate-d₅ is the deuterium labeled Felbamate . Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .

HY-18600AS

Azimilide-d8 dihydrochloride
Azimilide-d₈ (dihydrochloride) is the deuterium labeled Azimilide dihydrochloride. Azimilide Dihydrochloride (NE-10064 Dihydrochloride) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.

HY-W704787

Monoethyl fumarate-d5
Monoethyl fumarate-d₅ is the deuterium labeled Monoethyl fumarate (HY-W019696). Monoethyl fumarate is the monoethyl ester form of Fumaric acid (HY-W015883). Monoethyl fumarate is the activator for Nrf2. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material .

HY-W765014

Tolylfluanide-d7
Tolylfluanide-d₇ is the deuterium labeled Tolylfluanid (HY-W774955).

HY-144857S

Hydroxyhongdenafil-d4
Hydroxyhongdenafil-d₄ is the deuterium labeled Hydroxyhongdenafil (HY-W587964).

HY-W744525

Trihydroxycoprostane-d7
Trihydroxycoprostane-d₇ is the deuterium labeled Trihydroxycoprostane (HY-W740611).

HY-W704346

Dibutyldiethyltin-d18
Dibutyldiethyltin-d₁₈ is the deuterium labeled Dibutyldiethylstannane (HY-W710504).

HY-W738715

Potassium Azide-15N
Potassium Azide- ¹⁵N is the ¹⁵N labeled Potassium Azide (HY-W661390).

HY-W704349

Diphenyldiethyltin-d10
Diphenyldiethyltin-d₁₀ is the deuterium labeled Diethyldiphenylstannane (HY-W796152).

HY-16562S1

Irinotecan-d10 hydrochloride
Irinotecan-d₁₀ (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-16562S

Irinotecan-d10
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-W728545

Labetalol-d6 hydrochloride

Labetalol hydrochloride-d₆ (AH-5158 hydrochloride-d₆) is deuterium labeled Labetalol hydrochloride (HY-B1108). Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .

HY-W702453

Sodium dimethyl phosphate-d6
Sodium dimethyl phosphate-d₆ is the deuterium labeled Sodium dimethyl phosphate (HY-W793531).

HY-W588193S

Cortol-d5
Cortol-d₅ is deuterium-labeled Cortol (HY-W588193) .

HY-W738684

Biuret-15N3
Biuret- ¹⁵N₃ is the ¹⁵N labeled Biuret (HY-W015927).

HY-W777717

Methoxycarbonyl Cefadroxil-d6
Methoxycarbonyl Cefadroxil-d₆ is the deuterium labeled Methoxycarbonyl Cefadroxil (HY-W744948).

HY-144853S

Propoxyphenyl-thiohydroxyhomosildenafil-d4
Propoxyphenyl-thiohydroxyhomosildenafil-d₄ is the deuterium labeled Propoxyphenyl-thiohydroxyhomosildenafil (HY-W588226).

HY-W754223

N-Nitrosonortriptyline-d3
N-Nitrosonortriptyline-d₃ is the deuterium labeled N‐Nitrosonortriptyline (HY-W753949).

HY-170246S

N-Butylbenzenesulfonamide-d9
N-Butylbenzenesulfonamide-d₉ is the deuterium labeled N-Butylbenzenesulfonamide (HY-W014252).

HY-W742803

(R)-Sulindac-d6
(R)-Sulindac-d₆ is the deuterium labeled (R)-Sulindac (HY-W588246).

HY-W742793

cis-Phytoene-d6
cis-Phytoene-d₆ is the deuterium labeled cis-Phytoene (HY-W588218).

HY-W707748

trans-Metconazole-d6
trans-Metconazole-d₆ is the deuterium labeled trans-Metconazole (HY-W775391).

HY-W717660

Methyl diphenyl phosphate-d3
Methyl-d₃ diphenyl phosphate is the deuterium labeled Methyl diphenyl phosphate (HY-W290291).

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